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New cancer treatment uses enzymes to boost immune system and fight back

August 29, 2018/in News /by labadmin

In our most recent paper, we show that administration of a pharmacologically optimized enzyme (PEGylated kynureninase; hereafter referred to as PEG-KYNase) that degrades Kyn into immunologically inert, nontoxic and readily cleared metabolites inhibits tumor growth. Enzyme treatment was associated with a marked increase in the tumor infiltration and proliferation of polyfunctional CD8+ lymphocytes. We show that PEG-KYNase administration had substantial therapeutic effects when combined with approved checkpoint inhibitors or with a cancer vaccine for the treatment of large B16-F10 melanoma, 4T1 breast carcinoma or CT26 colon carcinoma tumors. PEG-KYNase mediated prolonged depletion of Kyn in the TME and reversed the modulatory effects of IDO1/TDO upregulation in the TME.

https://www.nature.com/articles/nbt.4180

http://www.worldpharmanews.com/research/4522-new-cancer-treatment-uses-enzymes-to-boost-immune-system-and-fight-back

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    GRA George Delidakis wins Poster Prize at EMBO Antibodies Conference Dr. Everett Stone Competes on Forged in Fire on the History Channel
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