In our most recent paper, we show that administration of a pharmacologically optimized enzyme (PEGylated kynureninase; hereafter referred to as PEG-KYNase) that degrades Kyn into immunologically inert, nontoxic and readily cleared metabolites inhibits tumor growth. Enzyme treatment was associated with a marked increase in the tumor infiltration and proliferation of polyfunctional CD8+ lymphocytes. We show that PEG-KYNase administration had substantial therapeutic effects when combined with approved checkpoint inhibitors or with a cancer vaccine for the treatment of large B16-F10 melanoma, 4T1 breast carcinoma or CT26 colon carcinoma tumors. PEG-KYNase mediated prolonged depletion of Kyn in the TME and reversed the modulatory effects of IDO1/TDO upregulation in the TME.
GRA George Delidakis recently attended the EMBO Antibody and Complement: Effector functions, Therapies and Technologies Conference in Girona, Spain and was awarded one of two Poster Awards.
The Conference was attended by an international group of faculty, students, and scientists from the biotech industry who work on understanding the diverse and complex roles of antibodies in the context of the broader immune system. In his poster, he presented our lab’s work on generating a panel of engineered antibodies which -unlike wildtype antibody- display unique specificity to each member of the Fc gamma receptor family, a family of receptors that are critical in linking the innate and adaptive branches of immunity. For his presentation, he was awarded one of the two Poster Awards, along with a cash prize.
The research was sponsored by the Clayton Foundation for Research.
Congratulations to Dr. Erik Johnson on his Data Scientist position at Epic Systems!
Congratulations Dr. Cantor on your new position at the Morgridge Institute!
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