In our most recent paper, we show that administration of a pharmacologically optimized enzyme (PEGylated kynureninase; hereafter referred to as PEG-KYNase) that degrades Kyn into immunologically inert, nontoxic and readily cleared metabolites inhibits tumor growth. Enzyme treatment was associated with a marked increase in the tumor infiltration and proliferation of polyfunctional CD8+ lymphocytes. We show that PEG-KYNase administration had substantial therapeutic effects when combined with approved checkpoint inhibitors or with a cancer vaccine for the treatment of large B16-F10 melanoma, 4T1 breast carcinoma or CT26 colon carcinoma tumors. PEG-KYNase mediated prolonged depletion of Kyn in the TME and reversed the modulatory effects of IDO1/TDO upregulation in the TME.
http://utw10696.utweb.utexas.edu/wp-content/uploads/2017/03/georgio_lab_logo.png 0 0 labadmin http://utw10696.utweb.utexas.edu/wp-content/uploads/2017/03/georgio_lab_logo.png labadmin2018-08-29 14:18:182018-08-29 14:18:18New cancer treatment uses enzymes to boost immune system and fight back